Scientific Newsletter Logo Retina International's

Scientific Newsletter


Animal Model Database
Other Vertebrates

Recent update from: 13.11.2002

You are always welcome to give your comments.

1. Fish
Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: archie

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Selective loss of ganglion and amacrine cells
Phenotype, clinic
Phenotype, electrophysiological
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: noa = No optokinetic response a

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Expanded chromophores
  • Abnormal melanophore size is light-dependent
  • Retina appears normal at 5 dpf
Phenotype, clinic
  • OKR is missing in white light
Phenotype, electrophysiological
  • Defect in synaptic transmission
  • b-wave severely reduced and delayed
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: nrb = No optokinetic response b

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Retina appears normal at 5 dpf
Phenotype, clinic
  • OKR is missing in white light
Phenotype, electrophysiological
  • Defect of photoreceptor adaptation
  • b-wave reduced and delayed
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: nrc = No optokinetic response c

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Tiering of photoreceptors absent at 6 dpf
  • Abnormal OPL
Phenotype, clinic
  • OKR is missing in white light
Phenotype, electrophysiological
  • b-wave reduced and delayed
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: poa = Partial optokinetic response a

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Retina appears normal at 5 dpf
Phenotype, clinic
  • OKR is small and quick (erratic) at all wavelength
Phenotype, electrophysiological
  • Normal ERG waveform
  • b-wave reduced in bright light
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: pob = Partial optokinetic response b

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Lighter colour
  • L-cones are missing at 5 dpf
Phenotype, clinic
  • OKR is missing in red light
  • Possible affection of pineal gland
Phenotype, electrophysiological
  • Defect in cell-type specific survival and/or function
  • No ERG above 580 nm
  • Larger-than-normal a-wave below 580 nm
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rerio

Race:

Occurrence of the model: Ethyl-nitrosourea-induced

 Disease: small eye

Inheritance:

Assignment:

Gene:

Mutation(s):

Phenotype, morphological
  • Non-specific retinal degeneration
  • Degeneration in the brain
Phenotype, clinic
Phenotype, electrophysiological
Phenotype, biochemical
Remarks
  • Zebrafish are tetrachromatic (L-, M-, S-, UV-cones)
Human counterpart:

Human disease:

Reference: (1)

Online Reference:

Online Data:

Species: Danio rero

Race: Mariner

Occurrence of the model:

Disease: Deafness

Inheritance:

Assignment:

Gene: myoVIIa

Mutation(s):

  • K533X
  • Y846X
  • C2144X
  • F516S
  • G2073D
Phenotype, morphological
  • Inner ear hair cell defect
  • Pronounced splaying of the stereocilia
Phenotype, clinic
  • Lack of vibrational sensitivity
Phenotype, electrophysiological
Phenotype, biochemical
Remarks
Human counterpart: MyoVIIa

Human disease: USH1B

 Reference: (2)

Online Reference:

Online Data:

References

  1. Brockerhoff,S.E., Dowling,J.E., and Hurley,J.B. Zebrafish retinal mutants. 1998; Vision Res. 38: 1335-1339.
    Link to PubMed
    Goto Top

  2. Ernest,S., Rauch,G.J., Haffter,P., Geisler,R., Petit,C., and Nicolson,T. Mariner is defective in myosin VIIA: a zebrafish model for human hereditary deafness. 2000; Hum.Mol.Genet. 9: 2189-2196.
    Link to PubMed
    Goto Top

Return to Retina International's
Scientific Newsletter
Database Page 		Return to Retina International's
Animal Model Database Page 		Return to Retina International's
Scientific Newsletter 		Return to pagehead

Contact the editor 		This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz