Retina International's Scientific Newsletter

	Retina International's Scientific Newsletter
	Mutation Database Mutations of the Tyrosinase Gene

Recent update from: 23.06.02

Phenotype	Mutation	Basechange	Nucleotide	Exon	Restriction Site	Classification & Remarks	Mutation Database	Reference
						The sequence data are adjusted to a sequence given in a WORD file which can be downloaded here. Nucleotides are counted from the translation start site as used in most of the recent publications of TYR mutations.
OCA1A	Deletion Exon1		0001	1		Compound: 730delTG		(4)
AROA	Met 1 Val	ATG-GTG	0001	1		Compound: R402Q M320Q Single complete loss of activity	CM981972	(5) (1)
OCA1A	Met 1 Thr	ATG-ACG	0002	1			CM981972
OCA1B	24delC	TGC CTG-TG_ CTG	0024	1		No compound	CD972506	(23)
OCA1A	52delG	GCT GGC-GCT G_C	0052	1		Heterozygous No compound	CD982992	(13) To online reference
OCA1A	His 19 Gln	CAT-CAA	0057	1		Heterozygous No compound	CM981973	(13) To online reference
OCA1A	Pro 21 Ser	CCT-TCT	0061	1			CM920692	(15) (14) (21) (20)
OCA1	Cys 36 Tyr	TGT-TAT	0107	1			CM992224	(18)
OCA1A	Asp 42 Gly	GAC-GGC	0125	1			CM910379	(15) (14) (21) (20)
OCA1A	Gly 47 Asp	GGC-GAC	0140	1	-HaeIII	Homozygous Compound: T373K L216M P81L 649del C	CM930711	(16) (14) (15) (21) (3) (20)
OCA1A	Ser 50 ter	TCA-TGA	0149	1		Homozygous	CM941343	(6)
OCA1A	Arg 52 Ile	AGA-ATA	0155	1		Heterozygous Compound: D383N	CM981974	(13) To online reference
AROA	Cys 55 Tyr	TGT-TAT	0164	1		Compound: R402Q	CM910380	(5) (14) (20)
OCA1A	Cys 55 Tyr	TGT-TAT	0165	1		Disrupts disulfide bond or elminates copper binding Compound: R402Q Single	CM910380	(15) (21) (30) (2) (5) To online reference
OCA1B	223delG	GTG GAT-GTG _AT	0222	1		Heterozygous No compound	CD982993	(13) To online reference
OCA2	Arg 77 Trp	CGG-TGG	0229	1		Compound: 1164delT	CM900220	(18)
OCA1B	Arg 77 Trp	CGG-TGG	0229	1		Heterozygous Compound: V275F reported as R77C (CGG-TGT)	CM971542	(13) (23) To online reference
OCA2	Arg 77 Gln	CGG-CAG	0230	1	-MspI	Compound: IVS2-7t-a	CM900220	(18) (3)
OCA1A	Arg 77 Gln	CGG-CAG	0230	1	-MspI	Compound: 926insC 731delGT -959delg + -801ins gagagggaga + -691ins c + -682ins g + -658del c R299H	CM900220	(15) (14) (21) (20) (26) (17) (18) (12)
OCA1B	Glu 78 ter	GAG-TAG	0232	1		Compound: G446S	CM971543	(23)
OCA1A	Glu 78 ter	GAG-TAG	0232	1		Compound: G446S	CM971543	(23)
OCA1	232insGGG	CGG GAG - CGG GGG GAG	0232	1				(30) To online reference
OCA1A	Trp 80 Arg	TGG-CGG	0238	1		Compound: G446S R402Q	CM971544	(23)
OCA1A	Trp 80 ter	TGG-TGA	0240	1		Heterozygous Compound: G47D	CM981975	(13) (3) To online reference
OCA1A	Pro 81 Leu	CCT-CTT	0242	1		Homozygous Compound: R217G N371T G47D G446S	CM900221	(8) (23) (16) (14) (18) (15) (21)
OCA1	Cys 89 Arg	TGC-CGC	0265	1	-BsrI	Resides in critical domain (C-G-N-C) conserved in TYR of different species and in TRP1 and TRP2 unprocessed and misfolded glycoform remains in ER possibly involved in C-C bonds	CM910381	(24) (20) (14) (15) (21) (10)
OCA1A	286insA	TTC ATG- TTC AAT G	0286	1			CI910577	(15) (14) (21) (20)
OCA1A	Gly 97 Arg	GGA-AGA	0289	1		Heterozygous Compound: 731delGT (affects EGF-like site) T373K	CM981976	(13) (18) To online reference
OCA	Gly 109 Arg	GGA-AGA	0325	1		Possibly affects protein interactions and glycosylation Compound: T373K		(3) To online reference
OCA	336delCA	TGC ACA GGA-TG_ _CA	0336	1		Compound: T373K	CD931054	(3) To online reference
OCA1A	340delGA	ACA GAG AGA CGA-ACA __G AGA CGA	0340	1		Homozygous Compound: R403S	CD931054	(15) (21) (18)
OCA1A	Arg 116 ter	CGA-TGA	0346	1		Heterozygous No compound	CM981977	(13) To online reference
OCA1	Pro 152 Ser	CCC-TCC	0456	1		Compound: A355A	CM941344	(6) (21)
OCA1	459insT	ATA GGG - ATT AGGG	0459	1		Compound: IVS2-7t-a T373K	CI992295	(18)
OCA1	Phe 176 Ile	TTT-ATT	0526	1			CM930712	(16) (14) (15) (21)
OCA1	Trp 178 ter	TGG-TAG	0533	1	+XbaI		CM910382	(7) (14) (15) (21) (20)
OCA1A	571delG	CTT GGG GGA-CTT _GG GGA	0568	1			CD910558	(15) (14) (21) (20)
Polymorphism	Ser 192 Tyr	TCT-TAT	0575	1	-DpnI, +MspI	Compound: R402Q - 27% activity at 37 C		(15) (14) (21) (20) (18)
OCA	Pro 205 Thr	CCA-ACA	0613	1		Impairs copper-binding		(3) To online reference
OCA1	Ala 206 Thr	GCT-ACT	0616	1	-AluI		CM910383	(11) (14) (15) (20)
OCA1	Leu 216 Met	TTG-ATG	0646	1		Compound: G47D	CM930713	(16) (14) (15) (21)
OCA	649delC	TTG CGG-TTG _GG	0649	1		Compound: R217W	CD941801	(21) (18)
OCA1A	Arg 217 Gly	CGG-GGG	0649	1	-AciI	Compound: P81L	CM971545	(23) (22)
OCA2	Arg 217 Trp	CGG-TGG	0649	1	-AciI	Compound: 649delC	CM920693	(18) (14) (20)
OCA1	Arg 217 Trp	CGG-TGG	0649	1	-AciI	Compound: 649delC	CM920693	(29) (15) (14) (21) (18)
OCA1	Arg 217 Gln	CGG-CAG	0650	1	-AciI	Compound: E294K	CM930714	(14) (15) (21) (18)
OCA	678delAGG	ACA GGA-AC_ __A	0678	1		Compound: T373K		(3) To online reference
OCA1	Trp 236 ter	TGG-TAG	0707	1		Homozygous	CM930715	(16) (20) (14) (15) (21)
OCA1	Trp 236 Ser	TGG-TCG	0707	1		Compound: F439V	CM930715	(18)
OCA1A	730delTG	AAG TGT GAC-AAG __T GAC	0730	1		Compound: IVS2-7t-a R77Q N371Y (OCA2) Deletion exon 1	CD910559	(15) (14) (21) (20) (18) (4)
OCA1A	Gly 253 Arg	GGA-AGA	0757	1	-MnlI	Homozygous	CM971546	(23)
OCA	His 256 Tyr	CAC-TAC	0766	1				(3) To online reference
OCA1	Trp 272 Cys	TGG-TGC	0816	1		Compound: R422Q	CM992226	(18)
OCA1	IVS1-3c-g	acag - agag	0820	2		Abberant splicing		(30) To online reference
OCA1	Val 275 Phe	GTC-TTC	0823	2			CM910384	(9) (14) (20)
OCA1B	Val 275 Phe	GTC-TTC	0825	2		Compound: R77W IVS2-1g-a	CM910384	(23) (15) (3)
OCA1	Arg 278 ter	CGA-TGA	0832	2			CM930716	(28) (6) (21) (20)
OCA1	840delG	GAG GAG-GA_ GAG	0840	2		Homozygous	CD992281	(18)
OCA1	871delTT	TCT TTA - TC_ _TA	0871	2				(30) To online reference
OCA1A	871delT	TCT TTA-TC_ TTA	0871	2		Compound: no	CD931055	(17) (20)
OCA1A	Cys 289 Arg	TGC-CGC	0875	2		Heterozygous Compound: M1T G446S	CM992227	(13) (18) To online reference
OCA1	Cys 289 Gly	TGC-GGC	0875	2		Disrupts disulfide bond, affecting protein folding and/or stability		(30) To online reference
OCA1	Glu 294 Lys	GAG-AAG	0890	2		Compound: IVS2-7 t-a R217Q	CM941345	(6) (18) (3)
OCA1	Glu 294 Gly	GAG-GGG	0891	2		Compound: R403S	CM9992227	(18)
OCA1	Arg 299 Ser	CGT-AGT	0895	2		Homozygous Disrupts copper binding	CM971547	(23) (30) (14) (20) To online reference
OCA1A	Arg 299 His	CGT-CAT	0896	2		Heterozygous Compound: 926insC Disrupts copper binding	CM920694	(29) (15) (6) (21) (17) (31) To online reference
OCA1	Arg 299 His	CGT-CAT	0896	2			CM920694	(17)
OCA1A	926insC	AGA ACC CCA AGG-AGA ACC CCC AAG G	0926	2		Compound: IVS2-10deltt-7t-a R77Q R299H No compound	CI910578	(15) (14) (21) (20) (30) (17) (27) (29)
OCA1A	Leu 312 Val	CTC-GTC	0934	2		Heterozygous Compound: P313R	CM981979	(13) To online reference
OCA1A	Pro 313 Arg	CCC-CGC	0938	2		Heterozygous Compound: L312V	CM981980	(13) To online reference
OCA1B	Thr 325 Ala	ACC-GCC	0973	2		No compound	CM971548	(23)
OCA1	Glu 328 Gln	GAA-CAA	0982	2	-HinfI		CM930717	(28) (21) (20)
OCA1A	Ser 339 Gly	AGC-GGC	1015	2	-AluI	No compound	CM971549	(23) (3)
OCA1B	Phe 340 Leu	TTT-CTT	1018	2		Heterozygous No compound	CM981981	(13) To online reference
OCA1B	IVS2-10deltt-7t-a	tttttaatgaa-ttt__aaagaa	1037	IVS2		Compound: 928insC		(17)
OCA1B	IVS2-7t-a	ttttgt-tttagt	1037	IVS2		Compound: S380P H390D 731delGT	CS930868	(23) (21) (18) (20) (19)
OCA1B	IVS2-1g-a	cagAT-caaAT	1037	IVS2		Compound: V275F	CS971924	(23)
OCA1B	Ala 355 Pro	GCG-CCG	1063	3	-AciI	Compound: D448N P406L R403S	CM971550	(23) (21) (20) (18) (3)
OCA1A	Gln 359 ter	CAA-TAA	1075	3		Compound: T373K	CM971551	(23)
OCA1A	Ser 361 Arg	AGC-CGC	1081	3				(25)
OCA1A	His 367 Arg	CAC-CGC	1100	3				(15)
OCA1	His 367 Tyr	CAC-TAC	1100	3			CM941346	(1)
OCA1	Met 370 Thr	ATG-ACG	1109	3		No Activity Compound: M1V R402Q	CM941347	(1)
OCA1A	Asn 371 Tyr	AAT-TAT	1111	3		Compound: 731delGT	CM992228	(18) (14) (25)
OCA1A	Asn 371 Thr	AAT-ACT	1112	3		Compound: P81L	CM930718	(16) (15) (21) (20)
OCA1A	Thr 373 Lys	ACA-AAA	1118	3		Compound: Q359X S395N 49insT A355P P406L 336delCA 678delAGG G109R R402Q Homozygous destroys glycosylation site at N371 retained in ER	CM900222	(23) (20) (16) (14) (15) (18) (6) (21) (3) (10) (1)
OCA1A	Gln 376 ter	CAG-TAG	1126	3	-MvaI		CM930719	(21) (20)
OCA1A	Gln 378 ter	CAG-TAG	1132	3	-Csp6I		CM920695	(15) (14) (20)
OCA1B	Ser 380 Pro	TCT-CCT	1138	3	-DpnI	Compound: IVS2-7t-a	CM971553	(23) (20)
OCA1A	Asn 382 Lys	AAC-AAA	1146	3			CM920696	(15) (21) (14) (20)
OCA1A	Asp 383 Asn	GAT-AAT	1147	3	-DpnI		CM900223	(15) (21) (3) (20) (17) (14)
OCA1A	1161delT	TTC CTT CTT-TTC C_T CTT	1160	3				(15)
OCA2	1163delT	CTT CAC-C_T CAC	1163	3			CD920914	(29) (18) (20)
OCA1B	His 390 Asp	CAT-GAT	1168	3	-NlaIII	Compound: IVS2-7t-a	CM971553	(23) (21) (20)
OCA1A	Ser 395 Asp	AGT-AAT	1183	4		Compound: T373K	CM971554	(23)
OCA1	Trp 400 Leu	TGG-TTG	1199	4		Disrupts copper binding		(30) To online reference
OCA1A	Arg 402 ter	CGA-TGA	1204	4		Homozygous	CM941348	(6) (21) (18) (20)
Polymorphism	Arg 402 Gln	CGA-CAA	1205	4		Temperature sensitive variant with permissive temperature at 32 C and non-permissive at 37 C At non permissive temperature retained in the ER bound to calnexin Compound: No	CM971555	(15) (21) (20)
AROA	Arg 402 Gln	CGA-CAA	1205	4		Temperature sensitive variant with permissive T at 32 C and non-permissive T at 37 C (27% activity of WT) Compound: C55Y M1V both on S195Y background M370T	CM971555	(10) (5) (1) (14) (20)
OCA1B	Arg 403 Ser	AGG-AGT	1209	4		Compound: A355P R403S E294G 344delGA	CM981982	(15) (14) (21) (20) (18)
OCA1A	His 404 Pro	CAC-CCC	1211	4		Heterozygous Compound: Q452X	CM910385	(13) To online reference
OCA1B	Pro 406 Leu	CCT-CTT	1217	4			CM910386	(15) (14) (21) (20) (18)
OCA1A	Gly 419 Arg	GGA-AGA	1255	4		Homozygous	CM910386	(15) (14) (21) (20) (18)
OCA1TS	Arg 422 Gln	CGG-CAG	1265	4		Compound: W272C	CM910687	(15) (14) (21) (20) (18) (2)
OCA1A	Pro 431 Leu	CCA-CTA	1292	4			CM930720	(21) (20)
OCA1A	1314delCTTT	TTC TTT ATT-TT_ ___ ATT	1314	4			CD920915	(15) (14) (21)
OCA1A	1315delTTTinsC	TTC TTT ATT-TTC CAT T	1314	4			CD920915	(2)
OCA1	Phe 439 Val	TTT-GTT	1315	5		Compound: W236S	CM992229	(18)
OCA1A	Gly 446 Ser	GGC-AGC	1336	4		Compound: E78S W80R C289R	CM920698	(23) (20) (15) (14) (18) (3)
OCA1A	Asp 448 Asn	GAC-AAC	1342	4		Homozygous Compound: A355P C289R	CM920699	(23) (20) (15) (14) (18)
OCA1A	Gln 453 ter	CAA-TAA	1357	4			CM920700	(15) (14)
OCA1B	IVS4+5a-g	aaa gt-aag gt	1366	IVS4		No compound	CS971925	(23)
OCA1B	IVS4+4a-g	aaa gt-aga gt	1366	IVS4				(20)
OCA1A	1467insT	ACT-ACTT	1467	5			CI910578	(15) (20) (14) (21)
OCA1A	1501insC	CGT-CCGT	1501	5			CI910579	(15) (14) (21) (20)
Polymorphism	-301c/t	aacct-aatct	-301	5'UTR				(14)
Polymorphism	-199c/a	tcgaa-tagaa	-199	5'UTR				(14)
Polymorphism	-658del c	tgcag ctatc-tg_ag ctatc	-658	5'UTR				(12)
Polymorphism	-682ins g	tgaac aaatc-tgaag caaatc	-682	5'UTR				(12)
Polymorphism	-691ins c	tatcc cacaa-tatcc ccaca a	-691	5'UTR				(12)
Polymorphism	-801ins gagagggaga	gaggg agagg-gaggg gagag ggaga agagg	-801	5'UTR				(12)
Polymorphism	-961del g	gaggg ggaga-gaggg g_aga	-961	5'UTR				(12)

References

Breimer,L.H., Winder,A.F., Jay,B., and Jay,M. Initiation codon mutation of the tyrosinase gene as a cause of human albinism. 1994; Clin.Chim.Acta. 227: 17-22.
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Breimer,L.H., Winder,A.F., Panayiotidis,P., Jay,M., Moore,A., and Jay,B. A trinucleotide deletion together with a base duplication event at codon 439 in the human tyrosinase gene identifies a mutational hotspot. 1995; Clin.Chim.Acta. 243: 35-42.
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Camand,O., Marchant,D., Boutboul,S., Pequignot,M., Odent,S., Dollfus,H., Sutherland,J., Levin,A., Menasche,M., Marsac,C., Dufier,J.L., Heon,E., and Abitbol,M. Mutation analysis of the tyrosinase gene in oculocutaneous albinism. 2001; Hum.Mutat. 17: 352
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Coupry,I., Taine,L., Goizet,C., Soriano,C., Mortemousque,B., Arveiler,B., and Lacombe,D. Leucodystrophy and oculocutaneous albinism in a child with an 11q14 deletion. 2001; J.Med.Genet. 38: 35-38.
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Fukai,K., Holmes,S.A., Lucchese,N.J., Siu,V.M., Weleber,R.G., Schnur,R.E., and Spritz,R.A. Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism. 1995; Nat.Genet. 9: 92-95.
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Gershoni Baruch,R., Rosenmann,A., Droetto,S., Holmes,S., Tripathi,R.K., and Spritz,R.A. Mutations of the tyrosinase gene in patients with oculocutaneous albinism from various ethnic groups in Israel. 1994; Am.J.Hum.Genet. 54: 586-594.
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Giebel,L.B., Musarella,M.A., and Spritz,R.A. A nonsense mutation in the tyrosinase gene of Afghan patients with tyrosinase negative (type IA) oculocutaneous albinism. 1991; J.Med.Genet. 28: 464-467.
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Giebel,L.B., Strunk,K.M., King,R.A., Hanifin,J.M., and Spritz,R.A. A frequent tyrosinase gene mutation in classic, tyrosinase- negative (type IA) oculocutaneous albinism. 1990; Proc.Natl.Acad.Sci.U.S.A. 87: 3255-3258.
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Giebel,L.B., Tripathi,R.K., Strunk,K.M., Hanifin,J.M., Jackson,C.E., King,R.A., and Spritz,R.A. Tyrosinase gene mutations associated with type IB ("yellow") oculocutaneous albinism. 1991; Am.J.Hum.Genet. 48: 1159-1167.
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Halaban,R., Svedine,S., Cheng,E., Smicun,Y., Aron,R., and Hebert,D.N. Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism. 2000; Proc.Natl.Acad.Sci.U.S.A. 97: 5889-5894.
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King,R.A., Mentink,M.M., and Oetting,W.S. Non-random distribution of missense mutations within the human tyrosinase gene in type I (tyrosinase-related) oculocutaneous albinism. 1991; Mol.Biol.Med. 8: 19-29.
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Matsunaga,J., Dakeishi,M., Miyamura,Y., and Tomita,Y. Sequence analysis of the human tyrosinase promoter from a patient with tyrosinase-negative oculocutaneous albinism. 1997; Pigment Cell Res. 10: 64-67.
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Oetting,W.S., Fryer,J.P., and King,R.A. Mutations of the human tyrosinase gene associated with tyrosinase related oculocutaneous albinism (OCA1). 1998; Hum.Mutat. 12: 433-434.
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Oetting,W.S. and King,R.A. Molecular basis of type I (tyrosinase-related) oculocutaneous albinism: mutations and polymorphisms of the human tyrosinase gene. 1993; Hum.Mutat. 2: 1-6.
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Oetting,W.S. and King,R.A. Analysis of tyrosinase mutations associated with tyrosinase- related oculocutaneous albinism (OCA1). 1994; Pigment Cell Res. 7: 285-290.
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Oetting,W.S., Witkop,C.J., Jr., Brown,S.A., Colomer,R., Fryer,J.P., Bloom,K.E., and King,R.A. A frequent tyrosinase gene mutation associated with type I-A (tyrosinase-negative) oculocutaneous albinism in Puerto Rico. 1993; Am.J.Hum.Genet. 52: 17-23.
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Park,S.K., Lee,K.H., Park,K.C., Lee,J.S., Spritz,R.A., and Lee,S.T. Prevalent and novel mutations of the tyrosinase gene in Korean patients with tyrosinase-deficient oculocutaneous albinism. 1997; Mol.Cells. 7: 187-191.
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Passmore,L., Kaesmann-Kellner,B., and Weber,B.H.F. Novel and recurrent mutations in the tyrosinase gene and the P gene in the German albino population. 1999; Hum.Genet. 105: 200-210.
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Schnur,R.E., Sellinger,B.T., Holmes,S.A., Wick,P.A., Tatsumura,Y.O., and Spritz,R.A. Type I oculocutaneous albinism associated with a full-length deletion of the tyrosinase gene. 1996; J.Invest.Dermatol. 106: 1137-1140.
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Spritz,R.A. Molecular genetics of oculocutaneous albinism. 1993; Semin.Dermatol. 12: 167-172.
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Spritz,R.A. Molecular genetics of oculocutaneous albinism. 1994; Hum.Mol.Genet. 3 Spec No: 1469-1475.
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Spritz,R.A., Lee,S.T., Fukai,K., Brondum Nielsen,K., Chitayat,D., Lipson,M.H., Musarella,M.A., Rosenmann,A., and Weleber,R.G. Novel mutations of the P gene in type II oculocutaneous albinism (OCA2). 1997; Hum.Mutat. 10: 175-177.
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Spritz,R.A., Oh,J., Fukai,K., Holmes,S.A., Ho,L., Chitayat,D., France,T.D., Musarella,M.A., Orlow,S.J., Schnur,R.E., Weleber,R.G., and Levin,A.V. Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1). 1997; Hum.Mutat. 10: 171-174.
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Spritz,R.A., Strunk,K.M., Hsieh,C.L., Sekhon,G.S., and Francke,U. Homozygous tyrosinase gene mutation in an American black with tyrosinase-negative (type IA) oculocutaneous albinism. 1991; Am.J.Hum.Genet. 48: 318-324.
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Summers,C.G., Oetting,W.S., and King,R.A. Diagnosis of oculocutaneous albinism with molecular analysis. 1996; Am.J.Ophthalmol. 121: 724-726.
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Takeda,A., Tomita,Y., Matsunaga,J., Tagami,H., and Shibahara,S. Molecular basis of tyrosinase-negative oculocutaneous albinism. A single base mutation in the tyrosinase gene causing arginine to glutamine substitution at position 59. 1990; J.Biol.Chem. 265: 17792-17797.
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Tomita,Y., Takeda,A., Okinaga,S., Tagami,H., and Shibahara,S. Human oculocutaneous albinism caused by single base insertion in the tyrosinase gene. 1989; Biochem.Biophys.Res.Commun. 164: 990-996.
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Tripathi,R.K., Bundey,S., Musarella,M.A., Droetto,S., Strunk,K.M., Holmes,S.A., and Spritz,R.A. Mutations of the tyrosinase gene in Indo-Pakistani patients with type I (tyrosinase-deficient) oculocutaneous albinism (OCA). 1993; Am.J.Hum.Genet. 53: 1173-1179.
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Tripathi,R.K., Strunk,K.M., Giebel,L.B., Weleber,R.G., and Spritz,R.A. Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions. 1992; Am.J.Med.Genet. 43: 865-871.
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Tsai,C.H., Tsai,F.J., Wu,J.Y., Lin,S.P., Chang,J.G., Yang,C.F., and Lee,C.C. Insertion/deletion mutations of type I oculocutaneous albinism in chinese patients from Taiwan. 1999; Hum.Mutat.Online. 14: 542
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Human Mutation Online
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Tsai,H.J., Ma,G.C., Wang,T.M., and Su,C.Y. Molecular Structures And Regulatory Elements Of The Commom Carp Rhodopsin Gene. 2000; Invest.Ophthalm.Vis.Sci. S389
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Contact the editor: irpamp@irpa.org	Return to Database Page	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz