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Retina International's Scientific Newsletter |
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The Protein Pages Tissue Inhibitor of Metalloproteases 3 (TIMP3) To see compiled data on further species click on the topics.
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Retina International's Scientific Newsletter |
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The Protein Pages Tissue Inhibitor of Metalloproteases 3 (TIMP3) To see compiled data on further species click on the topics.
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Recent update from: 08.07.00
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Description
The Tissue Inhibitor of Metalloproteases 3 (TIMP3) is a regulatory protein controlling tissue degradation in the eye by inhibiting proteases that breakdown proteins from ingested cells and cell parts (outer segments) in RPE. Exons: 5
Markers / RFLPs:
Transcripts:
Regulatory elements:
Primers:
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| Assignment: 22q12-13.2 | Involvement in Retinal Degenerations:
click here to see a compilation of
several Mutations found to underlie |
| Subunits: 1 | Amino acids: 188 AA |
| Modifications:
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Mr/ Weight:
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| Cofactors:
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Motifs:
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Click on entry to see database record online
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| Protein | Subtype | Locus | Species | EC-No. | Swissprot | PIR | Prosite |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Bos taurus | EC- | P20414 | A35685 B34468 B29712 A34833 I46979 | PS00288 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Bos taurus | EC- | P16368 | A35996 A34468 A25322 S28151 B35996 A34464 A34415 S21303 S20319 S17165 | PS00288 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Bos taurus | EC- | P79121 |
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| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Cricetus cricetus | EC- |
| S38624 |
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| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Gallus gallus | EC- | P26653 | A43429 A39043 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Homo sapiens | EC- | P01033 Q14252 | A20595 A48417 A35826 A93372 A23534 S20318 A93363 A01269 | PS00288 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Homo sapiens | EC- | P16035 | A37128 I53729 A34464 S20319 A34415 B35996 S21303 S17165 | PS00288 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Homo sapiens | EC- | P35625 | S45317 S59515 S53870 I38023 A49614 C56997 I53025 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Mus musculus | EC- | P12032 P20064 | A26106 A26917 A26633 A05276 | PS00288 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Mus musculus | EC- | P25785 | JH0683 JC1234 S18428 S15987 S26189 |
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| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Mus musculus | EC- | P39876 | A53532 S43053 A56937 B56937 I53108 S43052 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Oryctolagus cuniculus | EC- | P20614 | A33350 A30864 | PS00288 |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Ovis aries | EC- | P50122 | I46964 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Rattus norvegicus | EC- | P30120 P70533 | JC2557 B39120 S20326 |
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| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Rattus norvegicus | EC- | P30121 | S45683 I53415 S20325 S60160 |
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| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Rattus norvegicus | EC- | P48032 | JC4630 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Sus scrofa | EC- | P35624 |
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Click on entry to see database record online
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| Gene | Subtype | Locus | Species | Genbank | Unigene | Medline |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Bos taurus | S70841 M60073 |
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94257757 90365711 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Bos taurus | M32303 |
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90207285 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Bos taurus | U77588 |
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97138091 |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Equus caballus | U95039 |
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| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Gallus gallus | AF004664 |
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| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Gallus gallus | M94531 AF004664 M60412 M60413 |
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92381050 |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Homo sapiens | S68252 X03124 M12670 X02596 M59906 D11139 L47361 A10416 D26513 Y09720 L47357 M24603 X52828 X52829 X02598 NM_003254 | Hs.5831 | 94123576 86040463 86205964 85240564 91025550 97307877 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Homo sapiens | S68860 J05593 U44381 U44382 U44383 U44384 U44385 X54533 S48568 M32304 NM_003255 AH006644 | Hs.6441 | 90338014 94156197 96411768 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Homo sapiens | U02571 AF001361 U14394 U67195 S78453 S79779 X76227 U38952 S78453 D45917 U38953 U38954 U38955 U33110 U33111 U33112 U33113 U33114 U14394 Z98256 G06760 AL023282 L15078 NM_000362 AH006629 | Hs.245188 | 95201800 94215920 96091365 94228524 96235152 94245184 95290091 96033052 96042499 |
| Tissue Inhibitor of Metalloproteases | TIMP4 | TIMP | Homo sapiens | NM_003256 AH006411 U76456 | Hs.190787 |
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| Tissue Inhibitor of Metalloproteases | TIMP | Mus musculus | M28311 M28312 X04684 M17243 X69413 M21162 NM_011593 AH004952 M28308 M28309 M28310 M28311 | Mm.8245 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Mus musculus | M28308 M28309 M28310 M28311 M28312 X04684 M17243 X69413 |
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93042007 87066763 87218524 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Mus musculus | X62622 M93954 M21162 M65031 S37984 M82858 NM_011594 | Mm.19191 | 92290292 92347695 89096910 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Mus musculus | U19462 L19622 L15078 M28308 M28309 M28310 M28311 Z30970 U26433 U26437 U26434 U26435 U26436 Z31358 L27424 NM_011595 AH003325 | Mm.4871 | 94163596 95301511 94179361 95370262 95036582 |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Oryctolagus cuniculus | J04712 |
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89214135 |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Ovis aries | S67450 |
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94102210 |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Rattus norvegicus | U06179 L31883 L29512 U16022 |
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95011636 96317624 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Rattus norvegicus | S72594 S82718 U14526 L31884 |
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96384329 94263207 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Rattus norvegicus | U27201 NM_012886 | Rn.40532 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Sus scrofa | S67450 S96211 |
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92201478 |
Click on entry to see database record online
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| Gene | Subtype | Locus | Species | Genome Database | Mouse Genome Database | OMIM | Locus Link |
| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Homo sapiens | 119615 |
| 305370 |
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| Tissue Inhibitor of Metalloproteases | TIMP1 | TIMP | Homo sapiens |
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| 7076 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Homo sapiens | 132612 |
| 188825 | 7077 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Homo sapiens | 138175 |
| 188826 | 7078 |
| Tissue Inhibitor of Metalloproteases | TIMP4 | TIMP | Homo sapiens | 5584685 |
| 601915 | 7079 |
| Tissue Inhibitor of Metalloproteases | TIMP | Mus musculus |
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| 21857 | |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Mus musculus |
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| 21858 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Mus musculus |
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| 21859 |
| Tissue Inhibitor of Metalloproteases | TIMP4 | TIMP | Mus musculus |
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| 21860 |
| Tissue Inhibitor of Metalloproteases | TIMP2 | TIMP | Rattus norvegicus |
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| 29543 |
| Tissue Inhibitor of Metalloproteases | TIMP3 | TIMP | Rattus norvegicus |
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| 25358 |
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Contact the editor: irpamp@irpa.org |
This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz |
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