Scientific The Protein Pages

Rhodopsin (RHO)

Editor’s

To see compiled data on further species click on the topics.
To see the reference for the human data click on the data

Recent update from: 19.06.00

Description

Rhodopsin is a seven helix membran protein of rod photoreceptor outer segments. It starts the visual cascade on perception of light.

GENE DATA

Exons: 5

Markers / RFLPs:

Transcripts:

Regulatory elements:

3.3 kb promotor

Primers: Exon 1 - 5

Involvement in Retinal Degenerations:

click here to see a compilation of

CLICK

several Mutations found to underlie

Assignment: 3q21-q24

PROTEIN DATA
Subunits: 1 Amino acids: 348
Modifications:

Mr/ Weight:

40.000

Cofactors:

11-cis-retinal


PROTEIN DATA

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Protein Subtype Locus Species EC-No. Swissprot PIR Prosite
Rhodopsin
RHO Homo sapiens EC- P08100 I54264 I38158 A36235 A36537 A41200 PS00237 PS00238
Rhodopsin
PIGRHO1 Sus scrofa EC-


Rhodopsin

Limulus spec. EC- P35360 S14332 S29483 PS00237 PS00238
Rhodopsin
Rho Rattus norvegicus EC- P51489 S51677 PS00237 PS00238
Rhodopsin
Rho Canis familiaris EC- P32308 S32696 PS00237 PS00238
Rhodopsin

Octopus spec. EC- P09241 S00610 PS00237 PS00238
Rhodopsin

Xenopus laevis EC- P29403 S31474 S31473 I51200 PS00237 PS00238
Rhodopsin
Rho Bos taurus EC- P02699 A03154 A90840 A43773 A91306 A90115 A03154 PS00237 PS00238
Rhodopsin
Rho Ovis aries EC-
A30407 A90319 A93264 A03155
Rhodopsin
Rho Cricetulus griseus EC-
S23398
Rhodopsin
Rho Mus musculus EC- P15409 A23665 S01656 PS00237 PS00238
Rhodopsin

Gallus gallus EC- P22328 S29152 PS00237 PS00238
Rhodopsin

Carassius auratus EC-
C45229
Rhodopsin

Oryctolagus cuniculus EC- P49912 JC4267 PS00237 PS00238
Rhodopsin

Loligo spec. EC-
S14332 A60606 S29483

GENE DATA

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Gene Subtype Locus Species Genbank Unigene Medline
Rhodopsin
Rho Bos taurus K00502 K00503 K00504 K00505 K00506 M21606 U89240
84079861 84026485
Rhodopsin

Bufo bufo U59921

Rhodopsin

Bufo marinus U59922

Rhodopsin
Rho Canis familiaris Y09004 L77365 L77366 X71380
98182596
Rhodopsin

Carassius auratus L11863
93120096
Rhodopsin
Rho Cricetulus griseus


Rhodopsin

Gallus gallus M98497 D00702
89059271 95103025
Rhodopsin
RHO Homo sapiens U49742 K02281 S55797 S55799 S55874 S55843 S69937 S75470 S75471 S75472 S75473 S76516 S81166 S81169 X72315 U16824 M76676 S55843 G07162 NM_000539 Hs.247565 94214448 93271971 84272729 91377732 93138610 92112214 92120672 96142043 96144295 93138610
Rhodopsin

Limulus spec. L03781 L03791 X56788
93317641 91158727
Rhodopsin

Loligo spec. X56788
91158727
Rhodopsin
Rho Mus musculus M36695 M36696 M36697 M36698 M36699 M55171 Mm.2965 89005694 91056108
Rhodopsin

Octopus spec. E02902 X07797
88211878
Rhodopsin

Oryctolagus cuniculus U21688
96032368
Rhodopsin
Rho Ovis aries


Rhodopsin

Rana catesbeiana S79840
96070607
Rhodopsin

Rana pipiens S49004
93050229
Rhodopsin

Rana temporaria U59920

Rhodopsin
Rho Rattus norvegicus U22180 Z46957 U63971
95383121 93191719 91236741
Rhodopsin

Sepia officinalis AF000947
Rhodopsin
PIGRHO1 Sus scrofa AF008947
97475534
Rhodopsin

Xenopus laevis L07770 U23808 S62229 L04692

GENE LOCUS DATA

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Gene Subtype Locus Species Genome Database Mouse Genome Database OMIM Locus Link
Rhodopsin
RHO Homo sapiens 120347
180380 610
Rhodopsin
Rho Rattus norvegicus


24717
Rhodopsin
Rho Mus musculus
Rho
19747

References:
  1. Dryja,T.P., Hahn,L.B., Cowley,G.S., McGee,T.L., and Berson,E.L. Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa. 1991; Proc.Natl.Acad.Sci.U.S.A. 88: 9370-9374.
    Link Goto Top
  2. Hargrave,P.A. and McDowell,J.H. Rhodopsin and phototransduction: a model system for G protein- linked receptors. 1992; FASEB Journal. 6: 2323-2331.
    Link Goto Top
  3. Kaushal,S., Ridge,K.D., and Khorana,H.G. Structure and function in rhodopsin: the role of asparagine- linked glycosylation. 1994; Proc.Natl.Acad.Sci.U.S.A. 91: 4024-4028.
    Link Goto Top
  4. Nathans,J. Rhodopsin: structure, function, and genetics. 1992; Biochemistry. 31: 4923-4931.
    Link Goto Top
  5. Nathans,J. and Hogness,D.S. Isolation and nucleotide sequence of the gene encoding human rhodopsin. 1984; Proc.Natl.Acad.Sci.U.S.A. 81: 4851-4855.
    Link Goto Top
  6. Nathans,J., Thomas,D., and Hogness,D.S. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. 1986; Science. 232: 193-202.
    Link Goto Top
  7. Ohguro,H., Johnson,R.S., Ericsson,L.H., Walsh,K.A., and Palczewski,K. Control of rhodopsin multiple phosphorylation. 1994; Biochemistry. 33: 1023-1028.
    Link Goto Top
  8. Sparkes,R.S., Klisak,I., Kaufman,D., Mohandas,T., Tobin,A.J., and McGinnis,J.F. Assignment of the rhodopsin gene to human chromosome three, region 3q21-3q24 by in situ hybridization studies. 1986; Curr.Eye Res. 797-798. Link Goto Top
  9. Weng,J., Belecky Adams,T., Adler,R., and Travis,G.H. The Chicken Homolog Of RDS/Peripherin Is Expressed In Photoreceptor Outer Segments. 1996; Invest.Ophthalmol.Vis.Sci. S805 Goto Top

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Contact the editor 		This site is maintained and edited by
Dr. rer. medic. Markus Preising, Dipl.Biol.
Molecular Genetics Laboratory
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics
University of Regensburg
Head: Prof. Dr. med. Birgit Lorenz