Retina International's Scientific Newsletter - RPE-retinal G-protein-coupled Receptor

	Retina International's Scientific Newsletter
Editor's Notes from literature on RPE-retinal G-protein-coupled Receptor (RGR)

Recent update from: 03.01.2000

RGR,

Notes

Member of heptahelical receptor family
Resembles most closely the family of photoreceptors
In analogy to RHO a Lys is conserved in the seventh hydrophobic segment as a potential chromophor binding site
Localised in RPE and Müller cells

Species: Homo sapiens

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

mRNA: 1.5 kb

Exons:

Primers:

Protein Data

Amino acids: 291

Molecular weight	on SDS-PAGE: 32 kDa
	calculated: 31959

Reference: (1)

RGR,

Notes

Markers: D10S1786-RGR-D10S1658-D10S1744
2 families segregating 2 disease causing mutations
Light percieved by RGR converts atRal to 11cRAl (!)
Localized in RPE and Müller cells

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 10q23
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Amino acids:

Molecular weight	on SDS-PAGE:
	calculated:

Reference: (2)

References:

1. Jiang, M., Pandey, S., and Fong, H.K. An opsin homologue in the retina and pigment epithelium. 1993; Invest.Ophthalmol.Vis.Sci. 34: 3669 - 3678.
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2. Morimura, H., Saindelle-Ribeaudeau, F., Berson, E.L., and Dryja, T.P. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. 1999; Nat.Genet. 23: 393 - 394.
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Contact the editor: irpamp@irpa.org	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz