Retina International's Scientific Newsletter

	Retina International's Scientific Newsletter
Editor's Notes from literature on Myosin, unconventional

Recent update from: 19.12.1999

MYOX

Notes

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 5p15.1-p14.3
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (2)

MYOVA

Notes

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 15q21
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (2)

MYOD

Notes

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 19p13.3-p13.2
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (2)

MYOIC

Notes

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 15q21-q22
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (2)

Myo10

Notes

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse: 15

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (3)

Myo5a

Notes

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse: 9

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (3)

Myo1f

Notes

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse: 17

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (3)

Myo1e

Notes

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse: 9

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (3)

Myo1a

Notes

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse: 10

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (3)

MYOVIIA

Notes

5 mutations in motor domain, 3 mutations in tail
Localized to apical RPE process and periphery of connecting cilium
Abberant distribution of pigment molecules in shaker-1 mouse
Not dependend on own motor capability for localization
Required for normal RHO transport
Additional function in RPE

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (4)

MYOIA, 1a

Notes

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 12q13-q15
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (2)

MYOVIIA, type VIIa

Notes

Expression during embryogenesis in RPE cells only
Expression during adulthood in RPE cells and photoreceptors

Species: Homo sapiens

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (1)

MYOVIIA, type VIIa

Notes

Expression during embryogenesis and adulthood only in RPE cells
MyoVIIa may play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of OS disks
Expression in sensory hair cells of the otocyst and outer and inner hair cells of the cochlea

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (1)

MYOVIIA, type VIIa

Notes

Detected in cilia from cochlear hair cells, olfactory neurons, kidney distal tubules, lung bronchi
Cofractionate with the axonemal fraction of retinal photoreceptors
IR most concentrated in the periphery of the transition zone of cilia
Found in actin-rich microvilli of different cell types
Not found in the axoneme of spermatozoon
Expressed by several cells which posses microvilli
- microvilli of kidney proximal tubule
- supporting cells of olfactory epithelium
- lung bronchi
- brush border of intestine
- ectoplasmic specializations of testicular sertoli cells
Found in conjuction with other unconventional myosins
Only in photoreceptors are found to contain actin and cilia

Species: Mus musculus

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids:

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (5)

MYOVIIA, type VIIa

Notes

Spliced isoforms without tail
Walks along the connecting cilium on actin
moves membrane stretches out to the connecting cilium

Species: Rattus norvegicus

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Aminoacids: 2220 AA

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (6)

References:

1. El Amraoui, A., Sahly, I., Picaud, S., Sahel, J., Abitbol, M., and Petit, C. Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells. 1996; Hum.Mol.Genet. 5: 1171 - 1178.
Goto Top

2. Hasson, T., Skowron, J.F., Gilbert, D.J., Avraham, K.B., Perry, W.L., Bement, W.M., Anderson, B.L., Sherr, E.H., Chen, Z.Y., Greene, L.A., Ward, D.C., Corey, D.P., Mooseker, M.S., Copeland, N.G., and Jenkins, N.A. Mapping of unconventional myosins in mouse and human. 1996; Genomics. 36: 431 - 439.
Goto Top

3. Hasson, T., Walsh, J., Cable, J., Mooseker, M.S., Brown, S.D., and Steel, K.P. Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression. 1997; Cell Motil.Cytoskeleton. 37: 127 - 138.
Goto Top

4. Liu, C., Peng, M., Laties, A.M., and Wen, R. Exposure To Bright Light Activates Extracellular Signal-Regulated Protein Kinases In Photoreceptors And Muller Cells In Rat Retina. 1998; Invest.Ophthalmol.Vis.Sci. 39: S120
Goto Top

5. Wolfrum, U., Liu, X., Schmitt, A., Udovichenko, I.P., and Williams, D.S. Myosin VIIa as a common component of cilia and microvilli. 1998; Cell Motil.Cytoskeleton. 40: 261 - 271.
Goto Top Link to PudMed

6. Wolfrum, U. and Schmitt, A. Rhodopsin Transport In The Membrane Of The Photoreceptor Cilium And The Role Of Myosin VIIA,The Usher Syndrome 1b Gene Product. 1998; Invest.Ophthalmol.Vis.Sci. 39: S678
Goto Top

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Contact the editor: irpamp@irpa.org	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz