Retina International's Scientific Newsletter - Lecithin Retinol Acyltransferase

	Retina International's Scientific Newsletter
Editor's Notes from literature on Lecithin Retinol Acyltransferase (LRAT)

Recent update from: 06.02.2000

LRAT,

Notes

In subfractions of RPE microsomes together with 11-cis-RDH-> branch point of esterification and oxidation in ER of RPE
No LRAT in PM
Esterpool in PM serves as precursor store of chromophore synthesis

Species: Bos taurus

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

Exons:

Primers:

Protein Data

Amino acids:

Molecular weight	on SDS-PAGE:
	calculated:

Reference: (2)

LRAT,

Notes

Membrane bound
Expressed in fetal: RPE, liver, adult: RPE, prostate, testis, small intestine
Essential for biosynthesis of 11cRAl
Produces Ry for IMH

Species: Homo sapiens

See also:

Chromosomal localisation	in man:
	in mouse:

Gene Data

mRNA: 2615 bp

Exons:

Primers:

Protein Data

Amino acids: 230 AA

Molecular weight	on SDS-PAGE: 26 kDa
	calculated: 25.3 kDa

Reference: (1)

References:

1. Ruiz, A., Winston, A., Rando, R., and Bok, D. Molecular Cloning And Characterization Of Lecithin Retinol Acyltransferase (LRAT) In Human Retinal Pigment Epithelium. 1998; Invest.Ophthalmol.Vis.Sci. 39: S423
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2. Sierra, D.A., Tsin, A.T.C., Mata, N.L., and Villazana, E.T. Subcellular Distribution of 11-cis LRAT, 11-cis RD, and 11-cis REH in Bovine Pigment Epithelium. 1998; Invest.Ophthalmol.Vis.Sci. 39: S39
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Contact the editor: irpamp@irpa.org	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz