Retina International's Scientific Newsletter

	Retina International's Scientific Newsletter
Editor's Notes from literature on Crumbs Homologue 1 (CRB1)

Recent update from: 19.12.1999

CRB1

Notes

Expression in neural retina, fetal brain, and brain
Small polyA-tail, no polyadenylation signal
possible extracellular protein
35% identity; 55% similarity to Drosophila crb
19 EGF-like domains in 4 clusters
3 laminin A G-like (or ALPS) domains
C-type lectin domain
Domain arrangement conserved between man and drosophila
Genomic size: 40 kb

Species: Homo sapiens

See also:

Chromosomal localisation	in man: 1q31-32.1
	in mouse:

Gene Data

mRNA: 5.0

Exons: 11

Primers: complete

Protein Data

Aminoacids: 1376

Molecularweight	on SDS-PAGE:
	calculated:

Reference: (1)

References:

1. den Hollander, A.I., ten Brink, J.B., de Kok, Y.J., van Soest, S., van den Born, L.I., van Driel, M.A., van de Pol, D.J.R., Payne, A.M., Bhattacharya, S.S., Kellner, U., Hoyng, C.B., Westerveld, A., Brunner, H.G., Bleeker Wagemakers, E.M., Deutman, A.F., Heckenlively J.R., Cremers, F.P.M., Bergen, A.A.B., van de Pol, D.J., Bleeker-Wagemakers, E.M., Heckenlively, J.R., Cremers, F.P., and Bergen, A.A. Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). 1999; Nat.Genet. 23: 217 - 221.
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Contact the editor: irpamp@irpa.org	This site is maintained and edited by Dr. rer. medic. Markus Preising, Dipl.Biol. Molecular Genetics Laboratory Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics University of Regensburg Head: Prof. Dr. med. Birgit Lorenz