 |
Retina International's Scientific Newsletter |
|
|
The Protein Pages Cellular Retinaldehyde-binding Protein (CRAlBP, RLBP1) To see compiled data on further species click on the topics.
|
 |
|
Retina International's Scientific Newsletter |
|
|
The Protein Pages Cellular Retinaldehyde-binding Protein (CRAlBP, RLBP1) To see compiled data on further species click on the topics.
|
|
Recent update from: 09.01.2000
|
Description
Cellular Retinaldehyde-binding Protein (CRAlBP) is a watersoluble protein associated with the transport of 11-cis-RAl and 11-cis-Rol in the retina and RPE (10) , (1). The retina and pineal specific protein interacts with several retinoid processing enzymes including RDH thus supporting retinoid supply to retinal tissues (6), (7), (4) (3) Exons: 8
Markers / RFLPs:
D15S116
Regulatory elements:
PCE1 element at -243 to +80 Primers: Exons 2 -8 |
|
| Assignment: 15q26 | Involvement in Retinal Degenerations:
click here to see a compilation of
several Mutations found to underlie
|
| Subunits: 1 | Amino acids: 316 AA |
| Modifications: | Mr/ Weight: 36378 / 36 kDa |
| Cofactors: | |
Click on entry to see database record online
Return to page head
| Protein | Subtype | Locus | Species | EC-No. | Swissprot | PIR | Prosite |
| Cellular Retinaldehyde-binding Protein | RLBP1, CRALBP | Bos taurus | EC- | P10123 | A31955 A30052 |
| |
| Cellular Retinaldehyde-binding Protein | RLBP1, CRALBP | Homo sapiens | EC- | P12271 | A49185 A49185 |
|
Click on entry to see database record online
Return to page head
| Gene | Subtype | Locus | Species | Genbank | Unigene | Medline | |||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type I | CRABP1 | Bos taurus | M36808
X07436 M17253 |
BR>HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=91042593&dopt=Abstract">91042593
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=88185327&dopt=Abstract">88185327 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=87289661&dopt=Abstract">87289661 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type I | CRABP1 | Gallus gallus | X53701
Y12243 Y12244 |
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92155091&dopt=Abstract">92155091 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type II | CRABP2 | Gallus gallus | ||||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type I | RBP5, CRABP1 | Homo sapiens | S74445 | HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92104256&dopt=Abstract">92104256 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type II | CRABP2 | Homo sapiens | M97815
M68867 M97814 |
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=94350990&dopt=Abstract">94350990 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=93094236&dopt=Abstract">93094236 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=91373396&dopt=Abstract">91373396 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type I | CRABP1 | Mus musculus | S63446
X51715 X51716 X51717 X15789 X15481 M31552 M58013 M58014 M58015 X51827 |
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92037189&dopt=Abstract">92037189 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=91025549&dopt=Abstract">91025549 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=89339035&dopt=Abstract">89339035 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=89168179&dopt=Abstract">89168179 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=89313787&dopt=Abstract">89313787 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type II | CRABP2 | Mus musculus | M35523
M87538 M87539 M84142 M84143 L01528 |
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=92218442&dopt=Abstract">92218442 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=93008245&dopt=Abstract">93008245 HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=90349589&dopt=Abstract">90349589 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type I | CRABP1 | Rattus norvegicus | ||||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | type II | CRABP2 | Rattus norvegicus | U23407 | HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=95269720&dopt=Abstract">95269720 |
||||||||||||||||||||||||||||||
| Cellular Retinoic Acid-binding Protein | xCRABP | Xenopus laevis | S74933 | Return to page head
References: 1. Bunt Milam,A.H. and Saari,J.C. Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. 1983; J.Cell Biol. 97: 703-712. Goto Top Link to PudMed 2. Chen,Y., Goldflam,S., Johnson,C., West,K., and Crabb,J.W. The CRAlBP Retinoid Binding Domain. 1993; Invest.Ophthalmol.Vis.Sci. 34: 1198-1198. Goto Top 3. Crabb,J.W., Carlson,A., Chen,Y., Goldflam,S., Intres,R., West,K.A., Hulmes,J.D., Kapron,J.T., Luck,L.A., Horwitz,J., and Bok,D. Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein. 1998; Protein Sci. 7: 746-757. Goto Top Link to PudMed 4. Crabb,J.W., Gaur,V.P., Garwin,G.G., Marx,S.V., Chapline,C., Johnson,C.M., and Saari,J.C. Topological and epitope mapping of the cellular retinaldehyde- binding protein from retina. 1991; J.Biol.Chem. 266: 16674-16683. Goto Top Link to PudMed 5. Crabb,J.W., Goldflam,S., Harris,S.E., and Saari,J.C. Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures. 1988; J.Biol.Chem. 263: 18688-18692. Goto Top Link to PudMed 6. Crabb,J.W., Johnson,C.M., Carr,S.A., Armes,L.G., and Saari,J.C. The complete primary structure of the cellular retinaldehyde- binding protein from bovine retina. 1988; J.Biol.Chem. 263: 18678-18687. Goto Top Link to PudMed 7. Jones,S.E., Jomary,C., and Neal,M.J. Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa. 1994; FEBS Lett. 352: 171-174. Goto Top Link to PudMed 8. Kennedy,B.N., Goldman,S., Chang,M.A., Hackett,S., Campochiaro,P., Davis,A., Zack,D.J., and Crabb,J.W. Promotor Analysis of the Human CRALBP Gene. 1995; Invest.Ophthalmol.Vis.Sci. 36: S124 Goto Top 9. Maw,M.A., Kennedy,B., Knight,A., Bridges,R., Roth,K.E., Mani,E.J., Mukkadan,J.K., Nancarrow,D., Crabb,J.W., and Denton,M.J. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. 1997; Nat.Genet. 17: 198-200. Goto Top Link to PudMed 10. Saari,J.C., Bredberg,L., and Garwin,G.G. Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. 1982; J.Biol.Chem. 257: 13329-13333. Goto Top 11. Saari,J.C., Huang,J., Champer,R.J., Kennedy,B.N., Goldflam,S., and Crabb,J.W. Cloning of the mouse gene encoding cellular retinaldehyde binding protein (CRALBP). 1995; Invest.Ophthalmol.Vis.Sci. 36: S125 Goto Top 12. Sparkes,R.S., Heinzmann,C., Goldflam,S., Kojis,T., Saari,J.C., Mohandas,T., Klisak,I., Bateman,J.B., and Crabb,J.W. Assignment of the Gene (RLBP1) for Cellular Retinaldehyde- Binding Protein (CRALBP) to Human Chromosome-15q26 and Mouse Chromosome-7. 1992; Genomics. 12: 58-62. Goto Top Link to PudMed 13. Yuan,C.C., Crabb,J.W., Fishman,G.A., Jacobson,S.G., and Musarella,M.A. Exclusion of Cellular Retinaldehyde-binding Protein (CRAlBP) as a candidate gene for Stargardt's disease. 1994; Invest.Ophthalmol.Vis.Sci. 35: 1788-1788. Goto Top
| |||||||||||||||||||||||||||||||
